| Simon and Garfunkel | Simon Armitage | Simon Baker |
| Simon Bamberger | Simon Callow | Simon Cox (footballer, born 1987) |
| Simon Davies (footballer, born 1979) | Simon de Montfort, 6th Earl of Leicester | Simon Donaldson |
| Simon Elliott | Simon Flexner | Simon Kinberg |
| Simon Kjær | Simon Kuznets | Simon Mignolet |
| Simon Newcomb | Simon Ochley | Simon Ockley |
| Simon Pegg | Simon Plouffe | Simon Poulsen |
| Simon Pouplin | Simon Rolfes | Simon Stevin |
| Simon van der Meer | Simon's Cat | Simona Halep |
| Simone (2002 film) | Simone Barone | Simone Bentivoglio |
| Simone Bolelli | Simone de Beauvoir | Simone Del Nero |
| Simone Inzaghi | Simone Padoin | Simone Pepe |
| Simone Perrotta | Simone Pesce | Simone Scuffet |
| Simone Signoret | Simone Thiero | Simone Tiribocchi |
| Simone Verdi | Simone Vergassola | Simone Weil |
| Simone Zaza | Simonetta Sommaruga | Simonides of Ceos |
| Simonton, Texas | Simony | Simoom |
| Simorgh (rocket) | Simorhinella | Simpatico |
| Simple columnar epithelium | Simple DirectMedia Layer | Simple English Wikipedia |
| Simple eye in invertebrates | Simple group | Simple harmonic motion |
| Simple Linux Utility for Resource Management | Simple living | Simple machine |
| Simple Mail Transfer Protocol | Simple Network Management Protocol | Simple polygon |
| Simple series | Simple-type schizophrenia | Simplemente María |
| SimpleText | Simplex algorithm | Simplex Nthala |
| Simplified Chinese character | Simplified molecular input line entry specification | Simplified molecular-input line-entry system |
| Simpson and Delilah | Simpson County, Kentucky | Simpson Desert |
| Simpson's rule | Simpson, Illinois | Simpson, Kansas |
| Simpson, North Carolina | Simpsonville, Kentucky | Simpsonville, South Carolina |
| Sims | SIMS Co., Ltd. | Sims Township, Michigan |
| Sims, Illinois | Simula | Simulated annealing |
| Simulation | Simulation video game | SimulationX |
| Simulfix | Simuliidae | Simulink |
| Simultaneity | Simultaneous game | Simultaneous localization and mapping |
| Simvastatin | Sin | Sin by Silence |
| Sin City (film) | Sin City: A Dame to Kill For | Sin Li Mo |
| Sin Yong-nam | Sin-Itiro Tomonaga | Sina Corp |
| Sina Weibo | Sina, Iran | Sina.com |
| Sinai insurgency | Sinai peninsula | Sinai, South Dakota |
| Sinan Antoon | Sinan Bolat | Sinan Güler |
| Sinan ibn Thabit | Sinan Pasha Mosque (Damascus) | Sinan Pasha Mosque (Istanbul) |
| Sinan Pasha Mosque (Kaçanik) | Sinan Pasha Mosque (Prizren) | Sinan Tuzcu |
| Sinapis | Sinapis alba | Sinapis arvensis |
| Sinapis nigra | Sinān ibn al-Fatḥ | Sinbad: Legend of the Seven Seas |
| Since You Went Away | Sincere voting | Sinciput |
| Sinclair Lewis | Sinclair, Wyoming | Sinclairville, New York |
| Sind ibn Ali | Sindbis virus | Sindel |
| Sindhi language | Sine | Sine qua non |
| Sine wave | Sineh Sar | Sinemurian |
| Sing (2016 film) | Sing for the Moment | Sing If You Can |
| Sing Sing | Singapore | Singapore Airlines |
| Singapore Airshow | Singapore Botanic Gardens | Singapore Changi Airport |
| Singapore dollar | Singapore Strait | Singapore strategy |
| Singapura cat | Singe | Singer-songwriter |
| Singh Is Bliing | Singham | Singham Returns |
| Singing | Singing Revolution | Single (music) |
| Single crystal | Single molecule fluorescent sequencing | Single parent |
| Single person | Single player | Single point of failure |
| Single responsibility principle | Single umbilical artery | Single UNIX Specification |
| Single-cylinder engine | Single-elimination tournament | Single-gene disorder |
| Single-lens reflex camera | Single-Minute Exchange of Die | Single-nucleotide polymorphism |
| Single-party | Single-party state | Single-phase electric power |
| Single-photon avalanche diode | Single-photon emission computed tomography | Single-player video game |
| Single-sideband modulation | Single-stream recycling | Singrist |
| Singular value | Sinha (footballer) | Sinhala language |
| Siniša Mihajlović | Sink | Sinking Spring, Ohio |
| Sinningia | Sino-Soviet border conflict | Sino-Soviet conflict (1929) |
| Sino-Tibetan languages | Sinoatrial node | Sinodefence |
| Sinornithomimus | Sint Eustatius | Sint Maarten |
| Sint-Gillis-Waas | Sint-Jans-Molenbeek | Sint-Laureins |
| Sintashta | Sintering | Sinterklaas |
| Sinthaweechai Hathairattanakool | Sinton, Texas | Sinus rhythm |
| Sinus tubercle | Sinusitis | Sinusoidal Alternating current |
| Sinusotomy | Sinyal İstihbaratı Başkanlığı | SiO2 |
| Sioux | Sioux Center, Iowa | Sioux City, Iowa |
| Sioux language | Sioux Rapids, Iowa | Sipah-e-Sahaba Pakistan |
| Sipahi | Siphiwe Tshabalala | Siphon |
| Siphonaptera | Siphonophorae | Siphoviridae |
| Sipo (footballer) | SIPRI | Sipuncula |
| Siquijor | Sir Arthur Eddington | Sir Aurel Stein |
| Sir Francis Humphrys | Sir George Stokes, 1st Baronet | Sir George Trevelyan, 2nd Baronet |
| Sir H. Elliot | Sir H. M. Elliot | SIR HENRY ELLIOT |
| Sir Henry Rawlinson, 1st Baronet | Sir Henry Wellcome | Sir John Chardin |
| Sir John Retcliffe | Sir Kand | Sir Patrick Moore |
| Sir Stanley Spencer | Sir Thomas Adams Professor of Arabic | Sir Thomas Adams's Professor of Arabic |
| Sir Thomas Adams’ Professor of Arabic | Sir William Hamilton, 9th Baronet | Sir Yazjan-e Galeh Zan Abu ol Hasan Beygi |
| Sir Yazjan-e Galeh Zan Mazarai | Siracourt | Siraf |
| Siraj Al-Tall | Siraj Sikder | Sirajeddine Chihi |
| Sirajuddin Haqqani | Siren (alarm) | Siren (video game) |
| Siren, Wisconsin | Siren: Blood Curse | Sirenia |
| Siri | Sirius | Sirjan County |
| Sirkka Hämäläinen | Sirkka Turkka | Sirocco |
| Sirolimus | Sirous Dinmohammadi | Sirous Ghayeghran |
| Sirr Al-Khatim Al-Khalifa | Sirte | Sirwal |
| Sirzar, Lorestan | Sisavang Vatthana | Sisavang Vong |
| SISD | Sisimiut Airport | Sisinio González Martínez |
| Sisomicin | Sisor | Sisor barakensis |
| Sisor chennuah | Sisor pakistanicus | Sisor rabdophorus |
| Sisor rheophilus | Sisor torosus | Sisoridae |
| Sisorinae | Sisoroidea | Sisseton, South Dakota |
| Sissy Spacek | Sistan | Sistani Mahalleh |
