| Simile | Simin Behbahani | Simin Daneshvar |
| Simineh Rud Rural District | Simiyya | Simko Shikak |
| Simko Shikak revolt | Simla, Colorado | Simmondsia chinensis |
| Simnas | Simo Nikolić (footballer) | Simo Parpola |
| Simon & Schuster | Simon and Garfunkel | Simon Armitage |
| Simon Baker | Simon Bamberger | Simon Callow |
| Simon Cox (footballer, born 1987) | Simon Davies (footballer, born 1979) | Simon de Montfort, 6th Earl of Leicester |
| Simon Donaldson | Simon Elliott | Simon Flexner |
| Simon Kinberg | Simon Kjær | Simon Kuznets |
| Simon Mignolet | Simon Newcomb | Simon Ochley |
| Simon Ockley | Simon Pegg | Simon Plouffe |
| Simon Poulsen | Simon Pouplin | Simon Rolfes |
| Simon Stevin | Simon van der Meer | Simon's Cat |
| Simona Halep | Simone (2002 film) | Simone Barone |
| Simone Bentivoglio | Simone Bolelli | Simone de Beauvoir |
| Simone Del Nero | Simone Inzaghi | Simone Padoin |
| Simone Pepe | Simone Perrotta | Simone Pesce |
| Simone Scuffet | Simone Signoret | Simone Thiero |
| Simone Tiribocchi | Simone Verdi | Simone Vergassola |
| Simone Weil | Simone Zaza | Simonetta Sommaruga |
| Simonides of Ceos | Simonton, Texas | Simony |
| Simoom | Simorgh (rocket) | Simorhinella |
| Simpatico | Simple columnar epithelium | Simple DirectMedia Layer |
| Simple English Wikipedia | Simple eye in invertebrates | Simple group |
| Simple harmonic motion | Simple Linux Utility for Resource Management | Simple living |
| Simple machine | Simple Mail Transfer Protocol | Simple Network Management Protocol |
| Simple polygon | Simple series | Simple-type schizophrenia |
| Simplemente María | SimpleText | Simplex algorithm |
| Simplex Nthala | Simplified Chinese character | Simplified molecular input line entry specification |
| Simplified molecular-input line-entry system | Simpson and Delilah | Simpson County, Kentucky |
| Simpson Desert | Simpson's rule | Simpson, Illinois |
| Simpson, Kansas | Simpson, North Carolina | Simpsonville, Kentucky |
| Simpsonville, South Carolina | Sims | SIMS Co., Ltd. |
| Sims Township, Michigan | Sims, Illinois | Simula |
| Simulated annealing | Simulation | Simulation video game |
| SimulationX | Simulfix | Simuliidae |
| Simulink | Simultaneity | Simultaneous game |
| Simultaneous localization and mapping | Simvastatin | Sin |
| Sin by Silence | Sin City (film) | Sin City: A Dame to Kill For |
| Sin Li Mo | Sin Yong-nam | Sin-Itiro Tomonaga |
| Sina Corp | Sina Weibo | Sina, Iran |
| Sina.com | Sinai insurgency | Sinai peninsula |
| Sinai, South Dakota | Sinan Antoon | Sinan Bolat |
| Sinan Güler | Sinan ibn Thabit | Sinan Pasha Mosque (Damascus) |
| Sinan Pasha Mosque (Istanbul) | Sinan Pasha Mosque (Kaçanik) | Sinan Pasha Mosque (Prizren) |
| Sinan Tuzcu | Sinapis | Sinapis alba |
| Sinapis arvensis | Sinapis nigra | Sinān ibn al-Fatḥ |
| Sinbad: Legend of the Seven Seas | Since You Went Away | Sincere voting |
| Sinciput | Sinclair Lewis | Sinclair, Wyoming |
| Sinclairville, New York | Sind ibn Ali | Sindbis virus |
| Sindel | Sindhi language | Sine |
| Sine qua non | Sine wave | Sineh Sar |
| Sinemurian | Sing (2016 film) | Sing for the Moment |
| Sing If You Can | Sing Sing | Singapore |
| Singapore Airlines | Singapore Airshow | Singapore Botanic Gardens |
| Singapore Changi Airport | Singapore dollar | Singapore Strait |
| Singapore strategy | Singapura cat | Singe |
| Singer-songwriter | Singh Is Bliing | Singham |
| Singham Returns | Singing | Singing Revolution |
| Single (music) | Single crystal | Single molecule fluorescent sequencing |
| Single parent | Single person | Single player |
| Single point of failure | Single responsibility principle | Single umbilical artery |
| Single UNIX Specification | Single-cylinder engine | Single-elimination tournament |
| Single-gene disorder | Single-lens reflex camera | Single-Minute Exchange of Die |
| Single-nucleotide polymorphism | Single-party | Single-party state |
| Single-phase electric power | Single-photon avalanche diode | Single-photon emission computed tomography |
| Single-player video game | Single-sideband modulation | Single-stream recycling |
| Singrist | Singular value | Sinha (footballer) |
| Sinhala language | Siniša Mihajlović | Sink |
| Sinking Spring, Ohio | Sinningia | Sino-Soviet border conflict |
| Sino-Soviet conflict (1929) | Sino-Tibetan languages | Sinoatrial node |
| Sinodefence | Sinornithomimus | Sint Eustatius |
| Sint Maarten | Sint-Gillis-Waas | Sint-Jans-Molenbeek |
| Sint-Laureins | Sintashta | Sintering |
| Sinterklaas | Sinthaweechai Hathairattanakool | Sinton, Texas |
| Sinus rhythm | Sinus tubercle | Sinusitis |
| Sinusoidal Alternating current | Sinusotomy | Sinyal İstihbaratı Başkanlığı |
| SiO2 | Sioux | Sioux Center, Iowa |
| Sioux City, Iowa | Sioux language | Sioux Rapids, Iowa |
| Sipah-e-Sahaba Pakistan | Sipahi | Siphiwe Tshabalala |
| Siphon | Siphonaptera | Siphonophorae |
| Siphoviridae | Sipo (footballer) | SIPRI |
| Sipuncula | Siquijor | Sir Arthur Eddington |
| Sir Aurel Stein | Sir Francis Humphrys | Sir George Stokes, 1st Baronet |
| Sir George Trevelyan, 2nd Baronet | Sir H. Elliot | Sir H. M. Elliot |
| SIR HENRY ELLIOT | Sir Henry Rawlinson, 1st Baronet | Sir Henry Wellcome |
| Sir John Chardin | Sir John Retcliffe | Sir Kand |
| Sir Patrick Moore | Sir Stanley Spencer | Sir Thomas Adams Professor of Arabic |
| Sir Thomas Adams's Professor of Arabic | Sir Thomas Adams’ Professor of Arabic | Sir William Hamilton, 9th Baronet |
| Sir Yazjan-e Galeh Zan Abu ol Hasan Beygi | Sir Yazjan-e Galeh Zan Mazarai | Siracourt |
| Siraf | Siraj Al-Tall | Siraj Sikder |
| Sirajeddine Chihi | Sirajuddin Haqqani | Siren (alarm) |
| Siren (video game) | Siren, Wisconsin | Siren: Blood Curse |
| Sirenia | Siri | Sirius |
| Sirjan County | Sirkka Hämäläinen | Sirkka Turkka |
| Sirocco | Sirolimus | Sirous Dinmohammadi |
| Sirous Ghayeghran | Sirr Al-Khatim Al-Khalifa | Sirte |
| Sirwal | Sirzar, Lorestan | Sisavang Vatthana |
| Sisavang Vong | SISD | Sisimiut Airport |
| Sisinio González Martínez | Sisomicin | Sisor |
