| Silk road game | SilkAir | Silkroad Online |
| Silkwood | Silla | Silma Ihram |
| Silo | Siloam inscription | Siloam, Georgia |
| Silodosin | Silphidae | Silphium laciniatum |
| Silsbee, Texas | Silt | Silt, Colorado |
| Siltzheim | Silurian | Siluridae |
| Siluriformes | Silurus glanis | Silva Manso |
| Silvan Shalom | Silvano Pietra | Silvanus P. Thompson |
| Silver | Silver (color) | Silver acetate |
| Silver acetylide | Silver azide | Silver Bay, Minnesota |
| Silver Blaze | Silver carbonate | Silver carp |
| Silver certificate (United States) | Silver chlorate | Silver chloride |
| Silver chloride electrode | Silver chromate | Silver City, Iowa |
| Silver City, Mississippi | Silver Cliff, Colorado | Silver Cliff, Wisconsin |
| Silver Creek Township, Michigan | Silver Creek, Mississippi | Silver Creek, Missouri |
| Silver Creek, Nebraska | Silver Creek, New York | Silver cyanide |
| Silver diammine fluoride | Silver fulminate | Silver Grove, Kentucky |
| Silver halide | Silver hexafluorophosphate | Silver iodate |
| Silver iodide | Silver Lake, Kansas | Silver Lake, Minnesota |
| Silver Lake, Wisconsin | Silver Linings Playbook | Silver molybdate |
| Silver Nano | Silver nanoparticle | Silver nitrate |
| Silver Plume, Colorado | Silver ratio | Silver Springs, New York |
| Silver sulfate | Silver sulfide | Silver telluride |
| Silver tetrafluoroborate | Silver Wolf Award | Silver(I) fluoride |
| Silver(I) selenide | Silver(I,III) oxide | Silver(II) oxide |
| Silver-breasted Broadbill | Silver-oxide battery | Silverbell |
| Silverfish | Silverlight | Silverthorne, Colorado |
| Silverton, Colorado | Silverton, Oregon | Silverton, Texas |
| Silvester II | Silvestre de Sacy | Silvestre Igoa |
| Silvestre Varela | Silvetia | Silvetia babingtonii |
| Silvetia compressa | Silvetia siliquosa | Silvia Navarro |
| Silvia Navarro (handballer) | Silviabadeh | Silviculture |
| Silvio Berlusconi | Silvio Marić | Silvio Micali |
| Silvio Piola | Silvis, Illinois | Silviu Bindea |
| Silviu Lung | Silvology | Silya Magnana |
| Silybum | Silybum eburneum | Silybum marianum |
| Silymarin | Sima Qian | Sima Yi |
| Simakan Rural District | Simaroubaceae | Simarouboideae |
| Simas Jasaitis | Simão Sabrosa | Siméon Denis Poisson |
| Simón Bolívar | Simón Díaz | Simón Lecue |
| Simba | Simbi Khali | SimCity |
| SimCity (1989 video game) | SimCity (2013 video game) | SimCity 2000 |
| SimCity 3000 | SimCity 4 | SimCity 4: Rush Hour |
| SimCity 64 | SimCity Creator | SimCity DS |
| SimCity DS 2 | SimCity Social | SimCity Societies |
| Simd | SIMD | Simencourt |
| Simeon Masaba | Simeon Saxe-Coburg-Gotha | Simeon Slavchev |
| Simfibrate | Simi Valley, California | Simian vacuolating virus 40 |
| Simian virus 40 | Simiiformes | Similac |
| Similarity (geometry) | Simile | Simin Behbahani |
| Simin Daneshvar | Simineh Rud Rural District | Simiyya |
| Simko Shikak | Simko Shikak revolt | Simla, Colorado |
| Simmondsia chinensis | Simnas | Simo Nikolić (footballer) |
| Simo Parpola | Simon & Schuster | Simon and Garfunkel |
| Simon Armitage | Simon Baker | Simon Bamberger |
| Simon Callow | Simon Cox (footballer, born 1987) | Simon Davies (footballer, born 1979) |
| Simon de Montfort, 6th Earl of Leicester | Simon Donaldson | Simon Elliott |
| Simon Flexner | Simon Kinberg | Simon Kjær |
| Simon Kuznets | Simon Mignolet | Simon Newcomb |
| Simon Ochley | Simon Ockley | Simon Pegg |
| Simon Plouffe | Simon Poulsen | Simon Pouplin |
| Simon Rolfes | Simon Stevin | Simon van der Meer |
| Simon's Cat | Simona Halep | Simone (2002 film) |
| Simone Barone | Simone Bentivoglio | Simone Bolelli |
| Simone de Beauvoir | Simone Del Nero | Simone Inzaghi |
| Simone Padoin | Simone Pepe | Simone Perrotta |
| Simone Pesce | Simone Scuffet | Simone Signoret |
| Simone Thiero | Simone Tiribocchi | Simone Verdi |
| Simone Vergassola | Simone Weil | Simone Zaza |
| Simonetta Sommaruga | Simonides of Ceos | Simonton, Texas |
| Simony | Simoom | Simorgh (rocket) |
| Simorhinella | Simpatico | Simple columnar epithelium |
| Simple DirectMedia Layer | Simple English Wikipedia | Simple eye in invertebrates |
| Simple group | Simple harmonic motion | Simple Linux Utility for Resource Management |
| Simple living | Simple machine | Simple Mail Transfer Protocol |
| Simple Network Management Protocol | Simple polygon | Simple series |
| Simple-type schizophrenia | Simplemente María | SimpleText |
| Simplex algorithm | Simplex Nthala | Simplified Chinese character |
| Simplified molecular input line entry specification | Simplified molecular-input line-entry system | Simpson and Delilah |
| Simpson County, Kentucky | Simpson Desert | Simpson's rule |
| Simpson, Illinois | Simpson, Kansas | Simpson, North Carolina |
| Simpsonville, Kentucky | Simpsonville, South Carolina | Sims |
| SIMS Co., Ltd. | Sims Township, Michigan | Sims, Illinois |
| Simula | Simulated annealing | Simulation |
| Simulation video game | SimulationX | Simulfix |
| Simuliidae | Simulink | Simultaneity |
| Simultaneous game | Simultaneous localization and mapping | Simvastatin |
| Sin | Sin by Silence | Sin City (film) |
| Sin City: A Dame to Kill For | Sin Li Mo | Sin Yong-nam |
| Sin-Itiro Tomonaga | Sina Corp | Sina Weibo |
| Sina, Iran | Sina.com | Sinai insurgency |
| Sinai peninsula | Sinai, South Dakota | Sinan Antoon |
| Sinan Bolat | Sinan Güler | Sinan ibn Thabit |
| Sinan Pasha Mosque (Damascus) | Sinan Pasha Mosque (Istanbul) | Sinan Pasha Mosque (Kaçanik) |
| Sinan Pasha Mosque (Prizren) | Sinan Tuzcu | Sinapis |
| Sinapis alba | Sinapis arvensis | Sinapis nigra |
| Sinān ibn al-Fatḥ | Sinbad: Legend of the Seven Seas | Since You Went Away |
| Sincere voting | Sinciput | Sinclair Lewis |
| Sinclair, Wyoming | Sinclairville, New York | Sind ibn Ali |
| Sindbis virus | Sindel | Sindhi language |
